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KMID : 0438219780150030305
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Korea University Medical Journal
1978 Volume.15 No. 3 p.305 ~ p.312
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The influences of cocaine and calcium on responses of isolated rabbit organs to catecholamine
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Abstract
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There are many reports related with the potentiation mechanism of cocaine and the influence of calcium concentration on adrenergic responses.
But the interrelationship between cocaine and calcium in adrenergic responses of several isolated organs is now controversial. And, therefore, in order to study the influences of cocaine and calcium on the responses of isolated organs to catecholamine, the responses of isolated atria, aortic strip, splenic capsule and vas deferens of rabbits to norepinephrine and epinephrine were investigated after the preincubation of them with cocaine in normal Locke-Ringer bathing medium(L. R. medium: 2.4mM Ca++) and in half Ca++ Locke-Ringer bathing medium (h. Ca++L. R. medium: 1.2mM Ca++), respectively.
The results obtained were summarized as follows:
1. In L. R, medium, the responses of isolated atria, aortic strip and vas deferens to catecholamine were significantly augmented by the cocaine preincubation of them, but the response of splenic capsule was rather inhibited by the preincubation.
2. By the preincubation of isolated organs in half Ca++ L. R. medium, the responses of isolated atria and aortic strip to catecholamine were significantly augmented, and the response of was deferens was not affected, but the response of splenic capsule was rather inhibited.
3. In h. Ca++L. R. medium, the responses of isolated atria, aortic strip and vas deferens to catecholamine were significantly augmented by the cocaine preincubation of them.
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